000 05889nam a22006255i 4500
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003 DE-He213
005 20201213200815.0
007 cr nn 008mamaa
008 100315s2005 gw | s |||| 0|eng d
020 _a9783540317265
_9978-3-540-31726-5
024 7 _a10.1007/11560500
_2doi
050 4 _aQA75.5-76.95
072 7 _aUNH
_2bicssc
072 7 _aUND
_2bicssc
072 7 _aCOM030000
_2bisacsh
082 0 4 _a025.04
_223
100 1 _aR. Berthold, Michael.
_eeditor.
245 1 0 _aComputational Life Sciences
_h[electronic resource] :
_bFirst International Symposium, CompLife 2005, Konstanz, Germany, September 25-27, 2005. Proceedings /
_cedited by Michael R. Berthold, Robert C. Glen, Kay Diederichs, Oliver Kohlbacher, Ingrid Fischer.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2005.
300 _aXI, 277 p. Also available online.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aLecture Notes in Computer Science,
_x0302-9743 ;
_v3695
505 0 _aSystems Biology -- Structural Protein Interactions Predict Kinase-Inhibitor Interactions in Upregulated Pancreas Tumour Genes Expression Data -- Biochemical Pathway Analysis via Signature Mining -- Recurrent Neuro-fuzzy Network Models for Reverse Engineering Gene Regulatory Interactions -- Data Analysis and Integration -- Some Applications of Dummy Point Scatterers for Phasing in Macromolecular X-Ray Crystallography -- BioRegistry: A Structured Metadata Repository for Bioinformatic Databases -- Robust Perron Cluster Analysis for Various Applications in Computational Life Science -- Structural Biology -- Multiple Alignment of Protein Structures in Three Dimensions -- Protein Annotation by Secondary Structure Based Alignments (PASSTA) -- MAPPIS: Multiple 3D Alignment of Protein-Protein Interfaces -- Genomics -- Frequent Itemsets for Genomic Profiling -- Gene Selection Through Sensitivity Analysis of Support Vector Machines -- The Breakpoint Graph in Ciliates -- Computational Proteomics -- ProSpect: An R Package for Analyzing SELDI Measurements Identifying Protein Biomarkers -- Algorithms for the Automated Absolute Quantification of Diagnostic Markers in Complex Proteomics Samples -- Detection of Protein Assemblies in Crystals -- Molecular Informatics -- Molecular Similarity Searching Using COSMO Screening Charges (COSMO/3PP) -- Increasing Diversity in In-silico Screening with Target Flexibility -- Multiple Semi-flexible 3D Superposition of Drug-Sized Molecules -- Molecular Structure Determination and Simulation -- Efficiency Considerations in Solving Smoluchowski Equations for Rough Potentials -- Fast and Accurate Structural RNA Alignment by Progressive Lagrangian Optimization -- Visual Analysis of Molecular Conformations by Means of a Dynamic Density Mixture Model -- Distributed Data Mining -- Distributed BLAST in a Grid Computing Context -- Parallel Tuning of Support Vector Machine Learning Parameters for Large and Unbalanced Data Sets -- The Architecture of a Proteomic Network in the Yeast.
520 _aThe integration of knowledge in the life sciences is continuing apace with ev- increasingimportancebeing placedoncomputer-basedmethodsofdata capture, analysis, and knowledge representation. Today, our many di?erent sciences are providing us with a sea of information: it is the handling of this in?ux that is becoming a key discovery and regulatory question. The solutions to these problems will result in advancements to all of the involved sciences and will be highly in?uential both in the selection of the areas scientists seek to investigate and also on their success. For this to happen, it is crucial to establish an open and lively exchange between computer scientists, biologists, and chemists. To encourage precisely this type of exchange, crossing the borders of the sciences, we organized the 1st Symposium on Computational Life Science in Konstanz, Germany(September 25–27,2005). Themainobjectiveofthesymposiumwasto formbridges,bringingtogetherscientistsfromavarietyofdisciplinestoexchange ideas and research e?orts and to talk about the problems in areas of research that up until now have not been visible at an interdisciplinary level. Our conference program shows that the scienti?c mix worked out very well. From 49 submissions, 21 were selected for presentation at the symposium, c- ering areas ranging from high-level system biology to data analysis related to mass spec traces. As a supplement to the regularconference program,we dedicated one section to papers presentedinthe frameworkof a workshoponDistributed Data Mining in the Life Sciences (LifeDDM), organized by Giuseppe Di Fatta.
650 0 _aComputer science.
650 0 _aMedical records
_xData processing.
650 0 _aDatabase management.
650 0 _aInformation storage and retrieval systems.
650 0 _aInformation systems.
650 0 _aProteomics.
650 0 _aBioinformatics.
650 1 4 _aComputer Science.
650 2 4 _aInformation Storage and Retrieval.
650 2 4 _aHealth Informatics.
650 2 4 _aDatabase Management.
650 2 4 _aInformation Systems Applications (incl.Internet).
650 2 4 _aProteomics.
650 2 4 _aBioinformatics.
700 1 _aGlen, Robert C.
_eeditor.
700 1 _aDiederichs, Kay.
_eeditor.
700 1 _aKohlbacher, Oliver.
_eeditor.
700 1 _aFischer, Ingrid.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783540291046
830 0 _aLecture Notes in Computer Science,
_x0302-9743 ;
_v3695
856 4 0 _uhttp://dx.doi.org/10.1007/11560500
912 _aZDB-2-SCS
912 _aZDB-2-LNC
950 _aComputer Science (Springer-11645)
999 _c13734
_d13734